The present investigation deals with design and development of fast dissolving Celecoxib tablet by solid dispersion and camphor sublimation method using 32 Full Factorial design. The Celecoxib tablet prepared using solid dispersion of drug with carrier (PVP-K30) and different proportion of super disintegrants (Ac-Di-Sol). Drug was evaluated for bulk density, tapped density, Carr’s index and Hausner's Ratio. The different tablet (H1-H9) were prepared using solid dispersion of drug with carrier by direct compression method and evaluated for Compatibility study, Hardness, Thickness, Friability, Disintegration time and Wetting time. In vitro drug release profile of different batches (H1 to H9) was done by using USP type II apparatus. The optimized batch H7 was compared with marketed formulation and shows the better release (88.51%) than marketed formulation (80.71586%). Physical characterization of optimized formulation (H7) was done by FT-IR. Accelerated stability study was done to after 3 month. The Stability data indicate that formulation was stable at environmental condition. Camphor sublimation method was used to evaluate the effect of camphor on in vitro dissolution profile. The different proportion of independent variable (Ac-Di-Sol and Camphor) was used. The prepared formulation was evaluated for Hardness, Friability, Disintegration and drug content. From the different batches F8 shows 92.10% release in one hour. The FTIR spectrum of optimized formulation (F8) was done to check the interaction. It could be revealed that incorporation of camphor in tablet provide beneficial role in improving dissolution of drug.
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